Phrenic motoneuron and diaphragm development during the perinatal period
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Invited Review HIGHLIGHTED TOPIC Neural Control of Perinatal Respiration Key aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period
Mantilla CB, Sieck GC. Key aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period. J Appl Physiol 104: 1818–1827, 2008. First published April 10, 2008; doi:10.1152/japplphysiol.01192.2007.—At the time of birth, respiratory muscles must be activated to sustain ventilation. The perinatal development of respiratory motor units (comprising an individual motoneuro...
متن کاملKey aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period.
At the time of birth, respiratory muscles must be activated to sustain ventilation. The perinatal development of respiratory motor units (comprising an individual motoneuron and the muscle fibers it innervates) shows remarkable features that enable mammals to transition from in utero conditions to the air environment in which the remainder of their life will occur. In addition, significant post...
متن کاملContractile and fatigue properties of the rat diaphragm musculature during the perinatal period.
The following two hypotheses regarding diaphragm contractile properties in the perinatal rat were tested. First, there is a major transformation of contractile and fatigue properties during the period between the inception of inspiratory drive transmission in utero and birth. Second, the diaphragm muscle properties develop to functionally match changes occurring in phrenic motoneuron electrophy...
متن کاملElectrophysiological properties of rat phrenic motoneurons during perinatal development.
Past studies determined that there is a critical period at approximately embryonic day (E)17 during which phrenic motoneurons (PMNs) undergo a number of pivotal developmental events, including the inception of functional recruitment via synaptic drive from medullary respiratory centers, contact with spinal afferent terminals, the completion of diaphragm innervation, and a major transformation o...
متن کاملAn overview of phrenic nerve and diaphragm muscle development in the perinatal rat.
In this overview, we outline what is known regarding the key developmental stages of phrenic nerve and diaphragm formation in perinatal rats. These developmental events include the following. Cervical axons emerge from the spinal cord during embryonic (E) day 11. At approximately E12.5, phrenic and brachial axons from the cervical segments merge at the brachial plexi. Subsequently, the two popu...
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